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Trends Biochem Sci. 2012 Jul;37(7):293-302. doi: 10.1016/j.tibs.2012.03.004. Epub 2012 May 25.

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms.

Author information

1
Host-Pathogen Dynamics Group, Federated Department of Biological Sciences, Rutgers University, Newark, NJ, USA. nabonnet@andromeda.rutgers.edu

Abstract

Several RNA viruses have recently been shown to hijack members of the host phosphatidylinositol (PtdIns) 4-kinase (PI4K) family of enzymes. They use PI4K to generate membranes enriched in phosphatidylinositide 4-phosphate (PtdIns4P or PI4P) lipids, which can be used as replication platforms. Viral replication machinery is assembled on these platforms as a supramolecular complex and PtdIns4P lipids regulate viral RNA synthesis. This article highlights these recent studies on the regulation of viral RNA synthesis by PtdIns4P lipids. It explores the potential mechanisms by which PtdIns4P lipids can contribute to viral replication and discusses the therapeutic potential of developing antiviral molecules that target host PI4Ks as a form of panviral therapy.

PMID:
22633842
PMCID:
PMC3389303
DOI:
10.1016/j.tibs.2012.03.004
[Indexed for MEDLINE]
Free PMC Article

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