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Early Hum Dev. 2012 May;88 Suppl 2:S6-S10. doi: 10.1016/S0378-3782(12)70004-X.

Neonatal fungal infections: when to treat?

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1
Duke-National University of Singapore Graduate Medical School, Singapore.

Abstract

Candida infections are a major cause of morbidity and mortality in neonatal intensive care units. Mortality following Candida bloodstream infections is as high as 40%, and neurodevelopmental impairment is common among survivors. Because invasive fungal infections are common and extremely difficult to diagnose, empirical treatment with antifungal therapy should be considered in high-risk, low-birth-weight infants who fail to quickly respond to empirical antibacterial treatment. Risk factors to consider when deciding to administer empirical antifungal therapy include: prior exposure to third-generation cephalosporins, extreme prematurity, and presence of central venous catheters.

PMID:
22633516
PMCID:
PMC3512570
DOI:
10.1016/S0378-3782(12)70004-X
[Indexed for MEDLINE]
Free PMC Article
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