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Fertil Steril. 2012 Aug;98(2):347-54. doi: 10.1016/j.fertnstert.2012.04.041. Epub 2012 May 24.

Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers.

Author information

1
Center for Reproductive Medicine, Munich, Germany. r.ochsenkuehn@ivf-bbn.de

Abstract

OBJECTIVE:

To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture.

DESIGN:

Retrospective, observational, cohort study.

SETTING:

Private IVF center.

PATIENT(S):

A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Live birth rate.

RESULT(S):

Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥ 2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels <1.5 ng/mL (24.6%) and 1.5-1.99 ng/mL (26.7%). No such significant differences in live birth rates in cycles with GnRH antagonist could be observed.

CONCLUSION(S):

A rise of serum P levels ≥ 2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01426152.

[Indexed for MEDLINE]

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