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Trends Genet. 2012 Sep;28(9):436-44. doi: 10.1016/j.tig.2012.04.003. Epub 2012 May 24.

The adjustable nucleosome: an epigenetic signaling module.

Author information

1
Chromatin and Gene Expression Group, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk

Abstract

This review examines the proposition that the nucleosome, in addition to its role as a DNA packaging device, is a signaling module through which changing environmental and metabolic conditions can influence genomic functions. The role of enzyme-catalyzed post-translational modifications of the core histones is critically assessed, leading to the conclusion that they play varied, often crucial and sometimes causative roles in this signaling process.

PMID:
22633123
DOI:
10.1016/j.tig.2012.04.003
[Indexed for MEDLINE]

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