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Eksp Klin Gastroenterol. 2011;(11):15-26.

[Endotoxin (LPS) in the pathogenesis of atherosclerosis].

[Article in Russian]


Recent data on the processes underlying atherogenesis indicate the significant role of endotoxin (lipopolysaccharide - LPS) of the intestinal microflora in the development of vascular lesions. This paper summarizes the literature and material results of their research on the participation of LPS gramnegativnyh bacteria in the initiation and progression of atherosclerosis. We prove that the LPS of gram-negative bacteria interact with TLR4, triggers cytokine cascade with the subsequent formation of atheroma.

[Indexed for MEDLINE]

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