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Indian J Endocrinol Metab. 2012 May;16(3):414-6. doi: 10.4103/2230-8210.95685.

Pulmonary function tests in patients with primary hyperparathyroidism.

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1
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh (UT), India.

Abstract

CONTEXT:

There is limited information on respiratory muscle functions in patients with primary hyperparathyroidism (PHPT).

AIM:

To assess respiratory muscle dysfunction in patients with PHPT.

SETTING AND DESIGN:

This prospective study was carried between January 2005 and December 2006 by the Department of Endocrinology at the Postgraduate Institute of Medical Education and Research, Chandigarh.

MATERIALS AND METHODS:

PHPT was defined as elevated parathyroid hormone in the presence of hypercalcemia. Spirometry was performed using a dry rolling seal spirometer and spirometric indices like forced vital capacity (FVC), forced expiratory volume in first second (FEV(1)), and FEV(1)/FVC ratio were measured using standard guidelines.

RESULTS:

Thirty patients were studied with a mean age of 37.1 ± 2.4 years and 18 were women. The most common presenting symptoms were fatigue (75.0%) and bone pain (60.70%). The mean (±SD) of percentage predicted FVE(1), FVC, FEV(1)/FVC ratio, PEF, and FEF were 98.7 ± 16.1, 93.9 ± 14.7, 84.5 ± 3.4, 89.3 ± 22.5, and 99.7 ± 33.6, respectively. Two had obstructive lung disease and two had restrictive lung disease. We did not find correlation with preoperative serum calcium, phosphate, and PTH with FVE(1), FVC, FEV(1)/FVC ratio, PEF, and FEF.

CONCLUSION:

Elevated calcium, low phosphate, and elevated PTH levels in patients with moderate to severe PHPT do not significantly affect respiratory muscle functions.

KEYWORDS:

Primary hyperparathyroidism; pulmonary function test; restrictive lung disease

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