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J Pharmacol Pharmacother. 2012 Apr;3(2):161-71. doi: 10.4103/0976-500X.95520.

Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study.

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1
Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India.

Abstract

OBJECTIVE:

To investigate the effects of Celastrus paniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress.

MATERIALS AND METHODS:

An animal model of senile dementia of Alzheimer's type was produced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60 days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally.

RESULTS:

C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence.

CONCLUSION:

C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.

KEYWORDS:

Celapanin; Morris water maze test; celapagin; celapanigin; passive avoidance test; pyknosis; rotarod test; senile dementia of Alzheimer's type; sesquiterpene alkaloids

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