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Chest. 2012 Oct;142(4):909-18.

Secondhand smoke exposure predicted COPD and other tobacco-related mortality in a 17-year cohort study in China.

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1
Institute of Geriatrics, Chinese PLA General Hospital, Beijing, China. yhe301@x263.net

Abstract

BACKGROUND:

Prospective evidence on the association between secondhand smoke (SHS) and COPD and ischemic stroke is scarce.

METHODS:

We prospectively examined the relationship between SHS and major tobacco-related deaths, particularly COPD and stroke, in 910 Chinese (439 men, 471 women) who never smoked from a 17-year follow-up study in Xi’an, China. SHS exposure was defi ned as exposure to another person’s tobacco smoke at home or in the workplace.

RESULTS:

At baseline among the 910 subjects, 44.2% were exposed to SHS at home, 52.9% in the workplace, and 67.1% at home, work, or both. From March 1, 1994, to July 1, 2011, 249 (150 men,99 women) died within 14,016 person-years. Those who were exposed to SHS had increased mortality due to coronary heart disease (adjusted relative risk [RR], 2.15; 95% CI, 1.00-4.61), ischemic stroke (RR, 2.88; 95% CI, 1.10-7.55), lung cancer (RR, 2.00; 95% CI, 0.62-6.40), COPD (RR, 2.30;95% CI, 1.06-5.00), and all causes (RR, 1.72; 95% CI, 1.29-2.20), with significant dose-response relationships between cumulative SHS exposure at home and work and the increased risk of cause-specific and total mortality (P for linear trend ranged from .045 to , .001).

CONCLUSIONS:

This study shows dose-response relationships between SHS and major tobacco-related mortality and provides new evidence to support causation for COPD and ischemic stroke.

PMID:
22628493
DOI:
10.1378/chest.11-2884
[Indexed for MEDLINE]
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