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Chest. 2012 Dec;142(6):1482-1488. doi: 10.1378/chest.12-0494.

Clinical significance of the differentiation between Mycobacterium avium and Mycobacterium intracellulare in M avium complex lung disease.

Author information

1
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Seoul, South Korea. Electronic address: wjkoh@skku.edu.
2
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Seoul, South Korea.
3
Department of Laboratory Medicine, Seoul, South Korea.
4
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
5
Biostatistics Team, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, South Korea.
6
Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.

Abstract

BACKGROUND:

Mycobacterium avium and Mycobacterium intracellulare are grouped together as the M avium complex; however, little is known about the clinical impact of this species differentiation. This study compared the clinical features and prognoses of patients with M avium and M intracellulare lung disease.

METHODS:

From 2000 to 2009, 590 patients were given a new diagnosis of M avium complex lung disease; 323 (55%) had M avium lung disease, and 267 (45%) had M intracellulare lung disease.

RESULTS:

Compared with the patients with M avium lung disease, the patients with M intracellulare lung disease were more likely to have the following characteristics: older age (64 vs 59 years, P = .002), a lower BMI (19.5 kg/m² vs 20.6 kg/m², P < .001), respiratory symptoms such as cough (84% vs 74%, P = .005), a history of previous treatment for TB (51% vs 31%, P < .001), the fibrocavitary form of the disease (26% vs 13%, P < .001), smear-positive sputum (56% vs 38%, P < .001), antibiotic therapy during the 24 months of follow-up (58% vs 42%, P < .001), and an unfavorable microbiologic response after combination antibiotic treatment (56% vs 74%, P = .001).

CONCLUSIONS:

Patients with M intracellulare lung disease exhibited a more severe presentation and had a worse prognosis than patients with M avium lung disease in terms of disease progression and treatment response. Therefore, species differentiation between M avium and M intracellulare may have prognostic and therapeutic implications.

PMID:
22628488
DOI:
10.1378/chest.12-0494
[Indexed for MEDLINE]

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