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Small. 2012 Aug 20;8(16):2483-8. doi: 10.1002/smll.201200441. Epub 2012 May 25.

Curved biodegradable microneedles for vascular drug delivery.

Author information

1
School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.

Abstract

Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

PMID:
22628194
DOI:
10.1002/smll.201200441
[Indexed for MEDLINE]

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