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Thromb Haemost. 2012 Oct;108(4):592-8. Epub 2012 May 25.

Analytical challenges and technical limitations in assessing circulating miRNAs.

Author information

1
King's British Heart Foundation Centre, King's College London, London, UK. anna.zampetaki@kcl.ac.uk

Abstract

MiRNAs are emerging as promising biomarkers in cardiovascular diseases and may constitute a novel mechanism of intercellular communication. Accurate quantification of circulating miRNAs is essential. A variety of technological approaches and platforms have been developed with increased sensitivity and specificity for the detection and quantification of circulating miRNAs. In this review, we focus on the technical aspects and discuss the analytical challenges in profiling circulating miRNAs.

PMID:
22627831
DOI:
10.1160/TH12-02-0097
[Indexed for MEDLINE]

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