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Eye (Lond). 2012 Aug;26(8):1052-7. doi: 10.1038/eye.2012.86. Epub 2012 May 25.

Macular pigment optical density in wet age-related macular degeneration among Indians.

Author information

1
Shri Bhagwan Mahavir Vitreoretinal Services, Chennai, India. rajivpgraman@gmail.com

Abstract

PURPOSE:

To estimate the value of macular pigment optical density (MPOD) in adult south Indian population with wet age-related macular degeneration (AMD).

METHODS:

A total of 33 patients with wet AMD and 29 age-matched controls >50 years of age underwent MPOD measurement with the macular densitometer. The patients were also tested for their dietary intake of carotenoids, smoking history, and lifetime UV exposure.

RESULTS:

The mean MPOD values in the Indian population with wet AMD was 0.23 (95% CI: 0.18-0.29) vs control was 0.43 (95% CI: 0.37-0.49), P<0.0001, at 0.5° eccentricity. Ex-smokers had a lower MPOD than non-smokers (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), P=0.026) and the lowest level of carotenoids intake had 48% lower MPOD than the highest level (0.14 (0.08-0.21) vs 0.33 (0.24-0.43), P=0.012). There was no significant age-related decline or gender variation in MPOD.

CONCLUSION:

This study establishes the MPOD in adult Indian population with wet AMD, with a lack of macular pigment in association with wet AMD.

PMID:
22627475
PMCID:
PMC3420056
DOI:
10.1038/eye.2012.86
[Indexed for MEDLINE]
Free PMC Article

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