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Curr Opin Microbiol. 2012 Aug;15(4):500-5. doi: 10.1016/j.mib.2012.04.009. Epub 2012 May 23.

Inhibition and avoidance of mRNA degradation by RNA viruses.

Author information

1
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States.

Abstract

The cellular mRNA decay machinery plays a major role in regulating the quality and quantity of gene expression in cells. This machinery involves multiple enzymes and pathways that converge to promote the exonucleolytic decay of mRNAs. The transcripts made by RNA viruses are susceptible to degradation by this machinery and, in fact, can be actively targeted. Thus, to maintain gene expression and replication, RNA viruses have evolved a number of strategies to avoid and/or inactivate aspects of the cellular mRNA decay machinery. Recent work uncovering the mechanisms used by RNA viruses to maintain the stability of their transcripts is described below.

PMID:
22626865
PMCID:
PMC3424362
DOI:
10.1016/j.mib.2012.04.009
[Indexed for MEDLINE]
Free PMC Article

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