Send to

Choose Destination
Fitoterapia. 2012 Sep;83(6):1042-5. doi: 10.1016/j.fitote.2012.05.011. Epub 2012 May 22.

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus.

Author information

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.


Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC(50) values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 μM respectively.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center