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Fitoterapia. 2012 Sep;83(6):1042-5. doi: 10.1016/j.fitote.2012.05.011. Epub 2012 May 22.

Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus.

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.

Abstract

Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC(50) values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 μM respectively.

PMID:
22626747
DOI:
10.1016/j.fitote.2012.05.011
[Indexed for MEDLINE]

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