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Vopr Virusol. 2012 Jan-Feb;57(1):4-8.

[Estimation of the minimum infective doses of HIV in the prevalence of its infection].

[Article in Russian]


Estimation of the minimum human infective doses of HIV is essential to the prediction of its infection prevalence, including in bioterrorism. Information on the epidemiology and pathogenesis of HIV infection and on the biological properties of the pathogen may serve as reference data for the theoretical determination of a rough infective dose of HIV. The most common route of virus infection is parenteral transmission. The likelihood of HIV transmission through blood depends on the frequency of transfusions, the stage of HIV infection in a donor and the amount of blood given to a recipient. The author has analyzed the data available in the literature on the epidemiology and pathogenesis of the infection, on the properties of the pathogen, and on the risks of HIV infection in different groups and summarized information on the infection among injecting drug users, which could roughly estimate the level of sensitivity in man as a biological species to this virus.

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