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Neurosci Bull. 2012 Jun;28(3):309-15. doi: 10.1007/s12264-012-1232-8.

Planar cell polarity genes, Celsr1-3, in neural development.

Author information

1
Joint Laboratory for Brain Function and Health, Jinan University and The University of Hong Kong, Medical School of Jinan University, Guangzhou 510632, China.

Abstract

flamingo is among the 'core' planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1-3, are widely expressed in the nervous system. Recent work has shown that Celsr1-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.

PMID:
22622831
PMCID:
PMC5560321
DOI:
10.1007/s12264-012-1232-8
[Indexed for MEDLINE]
Free PMC Article

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