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Genome Biol. 2012;13(5):156.

Enhancer dysfunction: how the main regulators of gene expression contribute to cancer.

Author information

1
Department of Biological Chemistry and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geff en School of Medicine, University of California, Los Angeles, CA 90095, USA. skurdistani@mednet.ucla.edu

Abstract

A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.

PMID:
22621675
PMCID:
PMC3446281
DOI:
10.1186/gb-2012-13-5-156
[Indexed for MEDLINE]
Free PMC Article
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