Format

Send to

Choose Destination
EMBO J. 2012 Jun 13;31(12):2705-13. doi: 10.1038/emboj.2012.124. Epub 2012 May 22.

Mitotic and mitogenic Wnt signalling.

Author information

1
Division of Molecular Embryology, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany. niehrs@dkfz.de

Abstract

Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell proliferation by promoting G1 phase. In mitosis, components of the Wnt signalling cascade function directly in spindle formation. Moreover, Wnt signalling is strongly activated in mitosis, suggesting that 'mitotic Wnt signalling' plays an important role to orchestrate a cell division program. Here, we review the complex interplay between Wnt signalling and the cell cycle.

PMID:
22617425
PMCID:
PMC3380213
DOI:
10.1038/emboj.2012.124
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center