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J Infect Dis. 2012 Aug 1;206(3):319-23. doi: 10.1093/infdis/jis355. Epub 2012 May 21.

Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers.

Author information

1
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. M.Roestenberg@lumc.nl

Abstract

The development of a vaccine against malaria has public health priority. In a controlled setting, preliminary data on the efficacy of Plasmodium falciparum vaccine candidates can be obtained by exposing immunized human volunteers to the bites of laboratory-reared P. falciparum-infected mosquitoes. Using empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction. Sporozoite challenge trials are thus a powerful tool for early selection of candidates that warrant efficacy of trials in the field.

PMID:
22615322
DOI:
10.1093/infdis/jis355
[Indexed for MEDLINE]

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