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Chem Commun (Camb). 2012 Aug 25;48(66):8195-7. doi: 10.1039/c2cc32286b. Epub 2012 May 22.

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.

Author information

1
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Abstract

Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

PMID:
22614180
PMCID:
PMC3404228
DOI:
10.1039/c2cc32286b
[Indexed for MEDLINE]
Free PMC Article

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