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Trends Ecol Evol. 2012 Aug;27(8):428-35. doi: 10.1016/j.tree.2012.04.008. Epub 2012 May 19.

Physiological regulatory networks: ecological roles and evolutionary constraints.

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Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, CHUS-Fleurimont, 12ème Ave N, Sherbrooke, QC J1H 5N4, Canada.


Ecological and evolutionary physiology has traditionally focused on one aspect of physiology at a time. Here, we discuss the implications of considering physiological regulatory networks (PRNs) as integrated wholes, a perspective that reveals novel roles for physiology in organismal ecology and evolution. For example, evolutionary response to changes in resource abundance might be constrained by the role of dietary micronutrients in immune response regulation, given a particular pathogen environment. Because many physiological components impact more than one process, organismal homeostasis is maintained, individual fitness is determined and evolutionary change is constrained (or facilitated) by interactions within PRNs. We discuss how PRN structure and its system-level properties could determine both individual performance and patterns of physiological evolution.

[Indexed for MEDLINE]

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