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Nano Lett. 2012 Jun 13;12(6):2740-4. doi: 10.1021/nl204388p. Epub 2012 May 25.

Graphite nanoplatelets and Caenorhabditis elegans: insights from an in vivo model.

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1
Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

Abstract

We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also developed to analyze the GNPs spatial distribution inside the nematodes. Conflicting reports on the in vitro antimicrobial properties of graphene-based nanomaterials prompted us to challenge the host-pathogen system C. elegans-Pseudomonas aeruginosa to assess these findings through an in vivo model.

PMID:
22612766
DOI:
10.1021/nl204388p
[Indexed for MEDLINE]
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