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Aging Cell. 2012 Aug;11(4):722-5. doi: 10.1111/j.1474-9726.2012.00837.x. Epub 2012 Jun 11.

The number of p16INK4a positive cells in human skin reflects biological age.

Author information

1
Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Abstract

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.

PMID:
22612594
PMCID:
PMC3539756
DOI:
10.1111/j.1474-9726.2012.00837.x
[Indexed for MEDLINE]
Free PMC Article

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