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J Am Chem Soc. 2012 Jun 6;134(22):9098-101. doi: 10.1021/ja3030824. Epub 2012 May 24.

Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: indole synthesis from anilines and ketones.

Author information

1
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.

Erratum in

  • J Am Chem Soc. 2014 Feb 19;136(7):2928.

Abstract

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.

PMID:
22612535
DOI:
10.1021/ja3030824
[Indexed for MEDLINE]

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