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AIDS Patient Care STDS. 2012 Jun;26(6):312-9. doi: 10.1089/apc.2012.0044. Epub 2012 May 21.

Patient-reported symptoms on the antiretroviral regimen efavirenz/emtricitabine/tenofovir.

Author information

1
Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut, USA. ejennifer.edelman@yale.edu

Abstract

Most patients (80-90%) newly diagnosed with HIV are started on the antiretroviral regimen efavirenz, emtricitabine, and tenofovir (EFV/FTC/TDF). Existing studies of patient tolerability, however, are limited. We compared symptom experiences of patients on EFV/FTC/TDF, and the subsequent impact on health-related quality of life, with those of patients on other combination antiretroviral therapy (cART). We conducted a cross-sectional analysis of the Veterans Aging Cohort Study from February 2008 to August 2009 to compare the symptom experiences of patients on EFV/FTC/TDF vs. other cART, unadjusted and then adjusted for treatment characteristics, and comorbid disease severity. We then assessed the association between EFV/FTC/TDF use and health-related quality of life. Among the 1,759 patients in our analytic sample, EFV/FTC/TDF use was associated with fewer symptoms than was other cART. The use of EFV/FTC/TDF was independently associated with health-related quality of life, and this association was at least partially explained by symptom burden.

PMID:
22612469
PMCID:
PMC3412583
DOI:
10.1089/apc.2012.0044
[Indexed for MEDLINE]
Free PMC Article
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