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Int J Endocrinol. 2012;2012:414812. doi: 10.1155/2012/414812. Epub 2012 Apr 26.

Generation of transplantable Beta cells for patient-specific cell therapy.

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1
Department of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, Canada V5Z 4E3.

Abstract

Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.

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