Send to

Choose Destination
See comment in PubMed Commons below
Case Rep Ophthalmol. 2012 Jan;3(1):46-53. doi: 10.1159/000336276. Epub 2012 Feb 4.

Orbital aspergillosis: voriconazole - the new standard treatment?

Author information

Neuro-Ophthalmology Service, Department of Ophthalmology, University of Florida, Gainesville, Fla., USA.



To describe a case of invasive orbital aspergillosis and evaluate treatments and outcomes.


A case report and review of orbital aspergillosis treatment with voriconazole in the English language literature.


Amphotericin B with debridement is the current standard of care for orbital aspergillosis; however, its prognosis is unfavorable. When compared to amphotericin B, voriconazole demonstrates a survival benefit, has less systemic toxicity, and is better tolerated by patients. While a prospective trial comparing amphotericin B to voriconazole in orbital aspergillosis is not feasible, there is evidence to support the use of voriconazole as primary therapy.


Aspergillus fumigatus; Orbital apex syndrome; Orbital aspergillosis; Voriconazole

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Support Center