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Case Rep Ophthalmol. 2012 Jan;3(1):46-53. doi: 10.1159/000336276. Epub 2012 Feb 4.

Orbital aspergillosis: voriconazole - the new standard treatment?

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1
Neuro-Ophthalmology Service, Department of Ophthalmology, University of Florida, Gainesville, Fla., USA.

Abstract

BACKGROUND/AIM:

To describe a case of invasive orbital aspergillosis and evaluate treatments and outcomes.

METHODS:

A case report and review of orbital aspergillosis treatment with voriconazole in the English language literature.

CONCLUSION:

Amphotericin B with debridement is the current standard of care for orbital aspergillosis; however, its prognosis is unfavorable. When compared to amphotericin B, voriconazole demonstrates a survival benefit, has less systemic toxicity, and is better tolerated by patients. While a prospective trial comparing amphotericin B to voriconazole in orbital aspergillosis is not feasible, there is evidence to support the use of voriconazole as primary therapy.

KEYWORDS:

Aspergillus fumigatus; Orbital apex syndrome; Orbital aspergillosis; Voriconazole

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