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J Pathol. 2012 Aug;227(4):381-4. doi: 10.1002/path.4051. Epub 2012 Jul 2.

Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche.

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MRC Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh, UK.


Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known about how non-associated immune cells contribute to cancer biology. In a recent issue of the Journal of Pathology, He and colleagues use non-invasive, high-resolution imaging of the whole living animal to provide a compelling glimpse at how physiological migration of neutrophils can prepare a metastatic niche and how their activities can be altered by the unintended consequences of targeted therapeutics.

[Indexed for MEDLINE]

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