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Brain Behav Immun. 2013 Mar;30 Suppl:S75-87. doi: 10.1016/j.bbi.2012.05.001. Epub 2012 May 17.

Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

Author information

1
Duke Cancer Institute, Durham, NC 27710, USA.

Abstract

Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.

PMID:
22610066
PMCID:
PMC3638811
DOI:
10.1016/j.bbi.2012.05.001
[Indexed for MEDLINE]
Free PMC Article

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