Format

Send to

Choose Destination
Organogenesis. 2012 Apr-Jun;8(2):56-64. doi: 10.4161/org.19813. Epub 2012 Apr 1.

Extracellular matrix and cytoskeletal dynamics during branching morphogenesis.

Author information

1
Department of Chemical and Biological Engineering, Princeton University; Princeton, NJ USA.

Abstract

Branching morphogenesis is a fundamental developmental process which results in amplification of epithelial surface area for exchanging molecules in organs including the lung, kidney, mammary gland and salivary gland. These complex tree-like structures are built by iterative rounds of simple routines of epithelial morphogenesis, including bud formation, extension, and bifurcation, that require constant remodeling of the extracellular matrix (ECM) and the cytoskeleton. In this review, we highlight the current understanding of the role of the ECM and cytoskeletal dynamics in branching morphogenesis across these different organs. The cellular and molecular mechanisms shared during this morphogenetic process provide insight into the development of other branching organs.

PMID:
22609561
PMCID:
PMC3429513
DOI:
10.4161/org.19813
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center