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FEBS Lett. 2012 Jul 4;586(14):2016-25. doi: 10.1016/j.febslet.2012.05.011. Epub 2012 May 15.

Crosstalk between TGF-β and hedgehog signaling in cancer.

Author information

1
Institut Curie, Centre de Recherche, 91400 Orsay, France.

Abstract

Hedgehog (HH) and TGF-β signals control various aspects of embryonic development and cancer progression. While their canonical signal transduction cascades have been well characterized, there is increasing evidence that these pathways are able to exert overlapping activities that challenge efficient therapeutic targeting. We herein review the current knowledge on HH signaling and summarize the recent findings on the crosstalks between the HH and TGF-β pathways in cancer.

PMID:
22609357
DOI:
10.1016/j.febslet.2012.05.011
[Indexed for MEDLINE]
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