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Free Radic Biol Med. 2012 Aug 1;53(3):508-20. doi: 10.1016/j.freeradbiomed.2012.05.008. Epub 2012 May 15.

What really happens in the neutrophil phagosome?

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Department of Chemistry, Washington State University, Pullman, WA 99163, USA.


Current viewpoints concerning the bactericidal mechanisms of neutrophils are reviewed from a perspective that emphasizes challenges presented by the inability to duplicate ex vivo the intracellular milieu. Among the challenges considered are the influences of confinement upon substrate availability and reaction dynamics, direct and indirect synergistic interactions between individual toxins, and bacterial responses to stressors. Approaches to gauging relative contributions of various oxidative and nonoxidative toxins within neutrophils using bacteria and bacterial mimics as intrinsic probes are also discussed.

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