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Biochem Biophys Res Commun. 2012 Jun 15;422(4):615-20. doi: 10.1016/j.bbrc.2012.05.037. Epub 2012 May 15.

Surf4 modulates STIM1-dependent calcium entry.

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1
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.

Abstract

Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using affinity purification for STIM1-binding proteins and identified surfeit locus protein 4 (Surf4). Surf4 associated with STIM1 in the endoplasmic reticulum. Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE.

PMID:
22609200
DOI:
10.1016/j.bbrc.2012.05.037
[Indexed for MEDLINE]
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