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Curr Opin Chem Biol. 2012 Aug;16(3-4):355-61. doi: 10.1016/j.cbpa.2012.04.009. Epub 2012 May 18.

Bringing next-generation therapeutics to the clinic through synthetic biology.

Author information

1
Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.

PMID:
22609142
DOI:
10.1016/j.cbpa.2012.04.009
[Indexed for MEDLINE]

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