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Am J Obstet Gynecol. 2012 Jul;207(1):62.e1-7. doi: 10.1016/j.ajog.2012.04.035. Epub 2012 May 2.

Maternal BMI, glucose tolerance, and adverse pregnancy outcomes.

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1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology at University of North Carolina School of Medicine, Chapel Hill, NC 27599-7516, USA. astuebe@med.unc.edu

Abstract

OBJECTIVE:

The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.

STUDY DESIGN:

In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.

RESULTS:

Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass.

CONCLUSION:

Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

PMID:
22609018
PMCID:
PMC3482614
DOI:
10.1016/j.ajog.2012.04.035
[Indexed for MEDLINE]
Free PMC Article

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