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Prim Care. 2012 Jun;39(2):345-62. doi: 10.1016/j.pop.2012.03.007. Epub 2012 Apr 21.

Pharmacologic issues in management of chronic disease.

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Department of Pharmacy Practice, Jefferson School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Suite 1540, Philadelphia, PA 19107, USA.


A significant portion of the adult population uses one or more medications on a regular basis to manage chronic conditions. As the number of medications that patients are prescribed increases, an increase in pharmacologic-related issues and complications may occur, such as polypharmacy, inappropriate prescribing, medication nonadherence and nonpersistence, and adverse drug reactions and events. Risk factors and consequences of these issues have been identified and are discussed in this article. In addition, a review is presented of the numerous methods that have been evaluated to help prevent and minimize these pharmacologic issues in the management of chronic disease.

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