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Clin Exp Dermatol. 2013 Jan;38(1):36-9. doi: 10.1111/j.1365-2230.2012.04387.x. Epub 2012 May 21.

Scleromyxoedema with disseminated subcutaneous nodules: rare presentation of an uncommon dermatosis.

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Department of Dermatology and Venereology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.


Scleromyxoedema, also known as generalized lichen myxoedematosus, is a cutaneous mucinosis characterized by a generalized papular and sclerodermoid eruption, mucin deposition, increased fibroblast proliferation and fibrosis. It is often associated with underlying monoclonal gammopathy, and it responds poorly to treatment. There are very few reports of nodular eruption in scleromyxoedema. We report a case of a prominent nodular eruption in an adolescent boy with scleromyxoedema without any underlying paraproteinaemia, and review the literature.

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