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Int J Mol Sci. 2012;13(4):5179-94. doi: 10.3390/ijms13045179. Epub 2012 Apr 24.

Filamentous bacteriophage fd as an antigen delivery system in vaccination.

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1
Institute of Genetics and Biophysics, CNR, via P. Castellino 111, 80131, Naples, Italy.

Abstract

Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer's Disease and cancer.

KEYWORDS:

antigen delivery system; bacteriophage fd; vaccine

PMID:
22606037
PMCID:
PMC3344273
DOI:
10.3390/ijms13045179
[Indexed for MEDLINE]
Free PMC Article
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