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Genetics. 2012 Aug;191(4):1387-91. doi: 10.1534/genetics.112.141432. Epub 2012 May 17.

The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.

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1
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.

Abstract

Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.

PMID:
22595243
PMCID:
PMC3416016
DOI:
10.1534/genetics.112.141432
[Indexed for MEDLINE]
Free PMC Article
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