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Acta Paediatr. 2012 Aug;101(8):827-34. doi: 10.1111/j.1651-2227.2012.02729.x. Epub 2012 May 28.

A deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects.

Author information

1
Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305-5208, USA. rjwong@stanford.edu

Abstract

Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem degradation, plays a role in angiogenesis and vasculogenesis and is highly expressed in the placenta. Deficiencies in HO-1 are associated with several pregnancy disorders, such as recurrent miscarriages and pre-eclampsia. The unique combination of tissue protective, smooth muscle relaxing and angiogenesis regulatory properties makes HO-1 a key player in the maintenance of a healthy pregnancy through a direct effect on placental structural and vascular development, thus affecting foetal development.

CONCLUSION:

  Therefore, we conclude that HO-1 plays an important role in placental vasculature development and a deficiency in HO-1 may contribute to pregnancy complications, such as pre-eclampsia, spontaneous abortions and premature births.

[Indexed for MEDLINE]

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