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Mycoses. 2013 Mar;56(2):101-4. doi: 10.1111/j.1439-0507.2012.02210.x. Epub 2012 May 18.

Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study.

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1
Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic. zracil@fnbrno.cz

Abstract

There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3-β-D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty-six episodes of bacteraemia that occurred in high-risk haematological patients were included in our study. Consecutive BG levels >80 pg ml(-1) were required for test positivity. Only 2 of 26 patients were BG positive - both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients.

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