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Strategies and Protocols to Generate Mouse Models with Targeted Mutations to Analyze TRP Channel Functions.

Editors

In: Zhu MX1, editor.

Source

TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 8.

Author information

1
The University of Texas Health Science Center

Excerpt

Transient receptor potential (TRP) proteins constitute a superfamily of cation-permeable channels that show a broad range of activation, regulation, and selectivity mechanisms.1,2 Four TRP proteins are assumed to form homo-oligomeric and hetero-oligomeric channels, and the biological roles of TRP channels appear to be highly diverse. They essentially contribute to thermosensation and pain perception, Ca2+ and Mg2+ absorption, endothelial permeability, smooth muscle proliferation, and mast cell degranulation in mice and other mammals.3–5 The majority of our knowledge of the properties of TRP channels arises from diseases linked to mutations in TRP channels6,7 and from recordings of the activity of ectopically expressed TRP channel proteins in cell lines such as HEK 293 cells. In this environment, they do not necessarily act in accordance with the native cellular context as in primary cells.

Copyright © 2011 by Taylor and Francis Group, LLC.

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