Format

Send to

Choose Destination
Hippocampus. 2012 Nov;22(11):2095-100. doi: 10.1002/hipo.22032. Epub 2012 May 17.

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice.

Author information

1
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, F-33000 Bordeaux, France.

Abstract

Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial-maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD-induced hippocampal dysfunction at both behavioral and cellular levels.

PMID:
22593080
DOI:
10.1002/hipo.22032
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center