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Eur J Radiol. 2012 Nov;81(11):3229-33. doi: 10.1016/j.ejrad.2012.04.019. Epub 2012 May 14.

Outcome of breast lesions detected at screening ultrasonography.

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Department of Radiology, Seoul Metropolitan Government Seoul National University, Seoul National University Hospital, Boramae Medical Center, 41, Boramae-gil, Dongjak-gu, Seoul 156-707, Republic of Korea.



To assess the final outcome of breast lesions detected during screening ultrasonography (US) and categorized by BI-RADS final assessment.


During a 1-year period, 3817 consecutive asymptomatic women with negative findings at both clinical breast examinations and mammography underwent bilateral whole breast US and BI-RADS categories were provided for US-detected breast lesions. The reference standard was a combination of histology and US follow-up (≥12 months), and the final outcomes of 1192 US-detected lesions were analyzed.


Of 904 category 2 lesions, 890 remained stable for 12-60 months. Biopsies of 14 lesions revealed no malignancies (NPV=100%). Of 247 category 3 lesions, 232 remained stable for 12-60 months. Biopsies of 15 lesions revealed 2 malignancies, which were diagnosed within 6 months of the index examination and were node negative (NPV=99.2%). Of 41 category 4 lesions, biopsies of 38 lesions revealed 5 malignancies (PPV=12.2%), and 3 remained stable for 37-51 months. No US-detected lesion was classified as category 5.


The rates of malignancy for US-detected BI-RADS categories 2, 3, and 4 lesions were 0%, 0.8%, and 12.2%, respectively. The final assessment of US BI-RADS categorization showed it to be an appropriate predictor of malignancy for screening US-detected breast lesions.

[Indexed for MEDLINE]

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