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PLoS Pathog. 2012;8(5):e1002607. doi: 10.1371/journal.ppat.1002607. Epub 2012 May 10.

Vaccines against tuberculosis: where are we and where do we need to go?

Author information

1
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. t.h.m.ottenhoff@lumc.nl

Abstract

In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.

PMID:
22589713
PMCID:
PMC3349743
DOI:
10.1371/journal.ppat.1002607
[Indexed for MEDLINE]
Free PMC Article

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