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Malays J Med Sci. 2009 Apr;16(2):10-4.

The role of cells, neurotrophins, extracellular matrix and cell surface molecules in peripheral nerve regeneration.

Author information

1
Department of Anatomy, Faculty of Medicine, 50603 University Malaya, Malaysia.

Abstract

Wallerian degeneration is a complicated process whereby axons and myelin sheaths undergo degeneration, and eventually are phagocytosed by macrophages and Schwann cells following nerve damage. Schwann cells proliferate and the endoneural tubes persist. In addition, neurotrophins, neural cell adhesion molecules, cytokines and other soluble factors are upregulated to facilitate regeneration. The important role of cellular components, neurotrophins, and extracellular matrix components, including cell surface molecules involved in this regenerative process, is highlighted and discussed in this review.

KEYWORDS:

Schwann cells; cell surface molecules extracellular matrix; nerve growth factors; nerve regeneration; neurosciences

PMID:
22589652
PMCID:
PMC3336171
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