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Br J Cancer. 2012 Jun 26;107(1):158-60. doi: 10.1038/bjc.2012.194. Epub 2012 May 15.

The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.

Author information

1
Leaders in Oncology Care (LOC), 95 Harley Street, London W1G 6AF, UK. dkitchen@theloc.com

Abstract

BACKGROUND:

There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further.

METHODS:

From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin.

RESULTS:

A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78).

CONCLUSION:

This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.

PMID:
22588559
PMCID:
PMC3389405
DOI:
10.1038/bjc.2012.194
[Indexed for MEDLINE]
Free PMC Article

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