Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2012 May 16;13(6):397-404. doi: 10.1038/nrm3352.

Axis of ageing: telomeres, p53 and mitochondria.

Author information

1
Huffington Center On Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. esahin@bcm.edu

Abstract

Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.

PMID:
22588366
PMCID:
PMC3718675
DOI:
10.1038/nrm3352
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center