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Cancer Discov. 2011 Nov;1(6):466-8. doi: 10.1158/2159-8290.CD-11-0259.

Understanding the lethal variant of prostate cancer: power of examining extremes.

Author information

1
Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.

Abstract

Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN proto-oncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.

PMID:
22586648
PMCID:
PMC4133693
DOI:
10.1158/2159-8290.CD-11-0259
[Indexed for MEDLINE]
Free PMC Article

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