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J Surg Oncol. 2012 Dec;106(7):880-6. doi: 10.1002/jso.23154. Epub 2012 May 14.

PTK7 as a novel marker for favorable gastric cancer patient survival.

Author information

1
Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.

Abstract

BACKGROUND AND OBJECTIVES:

Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.

METHODS:

PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.

RESULTS:

PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).

CONCLUSION:

Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.

PMID:
22585737
DOI:
10.1002/jso.23154
[Indexed for MEDLINE]

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